Our philosophy
Our research philosophy is that the methods we develop should be user-friendly, experimentally trivial, environmentally friendly, and economically sound while providing access to otherwise difficult targets of structural and biological significance
Primary objectives
i) Development of novel stereoselective reactions relevant to both medicinal and natural product chemistry.
ii) Development of green and sustainable synthetic chemistry and atom economic reactions.
iii) Application of aforementioned strategies in the total synthesis of bioactive natural products and pharmaceutically important compounds.
Research areas in detail
I. Organocatalysis with phosphines​​ 
We routinely pursue metal-free chemistry with nucleophilic trivalent organophosphines. Some key contributions to this area include the development of asymmetric intramolecular Morita-Baylis-Hillman reaction and its variants, phosphine-promoted reductive- and vinylogous aldol reactions, phosphine-catalyzed intramolecular hydroalkylation, and hydroacylation chemistry, etc. Some of the advancements are summarized in the following figure.
Accounts and reviews in this area:
II. Pd-catalyzed annulative allylic alkylation chemistry
Our group actively works on developing novel Pd-catalyzed cycloisomerization reactions. We have showcased the utility of these methods in synthesizing many bioactive natural products. We have also assembled several intricate scaffolds through these strategies, which have relevance in medicinal chemistry and materials science. Some of the key contributions to this area are summarized below. 
III. New chemistry with sulphur ylides
Sulfur ylides are traditionally employed to synthesize cyclopropanes, epoxides, and aziridines from the respective olefins, carbonyls, and imines. We made a serendipitous entry into this field and articulated several one-pot cascade transformations employing sulfur ylides as reagents that provided facile access to unprecedented cyclopropanoids. We have manipulated the complexity of the molecular scaffolds by the rational design of the substrates. We have summarized some of the recent developments in the following figure.
IV. One-pot cascade transformations with Lewis and Brønsted acids/bases
We develop new methods by incorporating contemporary concepts in organic synthesis, such as cooperative catalysis, sequential/relay catalysis, domino/tandem processes, etc. Our contributions in this area can be divided into two categories based on metal-promoted and metal-free.
Metal-catalyzed one-pot cascades Metal-free one-pot cascades
First work in this area: Dhiman, S.; Ramasastry, S. S. V. Synthesis of Polysubstituted Cyclopenta[b]indoles via Relay Gold(I)/Brønsted Acid Catalysis. Chem. Commun. 2015, 51, 557.
Subsequent new developments: (i) First one-pot trimetallic orthogonal tandem catalysis: Angew. Chem. Int. Ed. 2016, 55, 7737.
(ii) One-pot tri- and tetrametallic orthogonal tandem catalysis: J. Org. Chem. 2017, 82, 6729.
First work in this area: Dhiman, S.; Ramasastry, S. S. V. Acid Catalyzed Ring Transformation of Benzofurans to Tri- and Tetrasubstituted Furans. J. Org. Chem. 2013, 78, 10427.
Subsequent new developments: (i) From furans to benzofurans: Chem. Comm. 2016, 52, 5569 [Highlighted in 'Synfacts']; Synthesis 2016, 48, 1865 [Invited]