In recent years, the directing group-aided or directing group-free C-H activation/functionalization is considered as a powerful method for installing functional groups in a given organic molecule. While a given organic molecule contains various C-H bonds, one of the main objectives of our research is to accomplish regio- and stereoselective (site-selective) functionalization of C-H bonds of small organic molecules. Our group is actively working on various projects pertaining to directing group-aided or directing group-free C-H activation/functionalization.
General Theme
The metal-mediated additions of nucleophiles to carbonyls or imines are remarkable C-C bond forming synthetic transformations. Our group is involved in using the Barbier-/Reformatksy-type reactions for the stereoselective synthesis of aliphatic chains, carbo- and heterocyclic frameworks related to natural products and bioactive synthetic molecules e.g. isoindolinones, lactones, lactams, amino alcohols, unnatural amino acid derivatives, etc
Since the discovery of crown ethers, polyether macrocycles have significantly attracted attention given their invaluable properties and applications in chemical and biological sciences and industry and various methods have been reported for obtaining the macrocycles. Our group is involved in synthesizing novel racemic and optically enriched polyether macrocycles using simple amino acid / amino alcohol building blocks.
The recovery and reuse of catalysts in organic transformations is an important process in the development of sustainable synthetic protocols in light of green chemistry. Numerous organic transformations have been reported using plethora of heterogeneous catalysts. In recent years, loading the catalysts onto magnetic nanoparticles or using magnetic nanoparticles as the catalysts have received considerable attention because the magnetically supported catalysts can be easily recovered after the desired chemical transformations. Part of our groups research programme is to develop synthetic transformations catalysed by magnetically supported catalysts.
Several classes of small organic molecules including naturally occurring molecules are used for treating Malaria disease. Due to the gradual decrease in the efficacy of some of the drug molecules available for treating Malaria disease, there is a demand for finding new synthetic drug molecules for treating Malaria disease. Given that there is a demand for finding new synthetic drug molecules for treating Malaria disease one of the objectives of our lab is to synthesize novel oxindoles/trioxanes/tetraoxanes and identify their antimalarial activity.
