Patents

 

 

Patents Granted and Patent Applications:

 

(11) Inventors: Srinivasarao Arulananda Babu, Sivapriya Kirubakaran, Ramandeep Kaur and Haritha Dilip

 

Patent Application No. 202411072578

Filing date: 25 September 2024.

 

Title: Biaryl-Based Carbazoles For The Treatment Of Cancer And Preparation Thereof Via C-H Functionalization

 

(10) Inventors: Srinivasarao Arulananda Babu and Nayyar Ahmad Aslam

 

Patent Application No. 2811/DEL/2011, Date: 27th  September 2011

Patent No. 299372 (Granted on 27.07.2018) 

 

Title: Stereoselective preparation of functionalized beta, beta’-disubstituted- and beta, beta’, beta’’- trisubstituted alpha-amino acid derivatives at least with two contiguous stereocenters

 

  

(9) Inventors: Srinivasarao Arulananda Babu and Nayyar Ahmad Aslam

 

Patent Application No. 3400/DEL/2013, Date: 20th November 2013

Patent No. 411834 (Granted on 18.11.2022).

 

Title: Process for the Preparation of Homoserine Lactones Derivatives

 

 

 (8) Inventors: Srinivasarao Arulananda Babu and Naveen

 

Patent Application No. 2152/DEL/2013, Date: 18th  July 2013

Patent No. 491810 (Granted on 29.12.23).

Title: Novel Class of Crown Ether/Polyether Macrocyclic Compounds and the Process of Preparation Thereof

 

 

(7) Inventors: Srinivasarao Arulananda Babu, Ramarao Parella and Bojan Gopalakrishnan

 

Patent Application No. 1240/DEL/2013, Date: 26th April 2013

Patent No. 466019 (Granted on 06.11.23). 

Title: Novel Di- and Trisubstituted Cyclopropanecarboxamide compounds and the Process of Preparation Thereof

 

  

(6) Inventors: Srinivasarao Arulananda Babu and Vadla Rajkumar

 

Patent Application No. 1102/DEL/2013, Date: 12th April 2013

Patent No. 382972 (Granted on 29.11.2021)

 

Title: Novel Nicotine Analogues/2-Pyridylpyrrolidine Derivatives and the Process of Preparation Thereof

 

  

(5) Inventors: Srinivasarao Arulananda Babu and Nayyar Ahmad Aslam

 

Patent Application No. 295/DEL/2013, Date: 2nd February 2013

Patent No. 374470 (Granted on 13.08.2021) 

 

Title: A stereoselective method for the preparation of beta-alkyl N-substituted aspartic acid derivatives

 

  

(4) Inventors: Srinivasarao Arulananda Babu and Naveen

 

Patent Application No. 3532/DEL/2012, Date: 16th November 2012

Patent No. 404710 (Granted on 26.08.2022)

 

Title: Preparation of new crown ether/polyether macrocyclic systems

 

 

(3) Inventors: Makoto Yasuda, Akio Baba, Srinivasarao Arulananda Babu, Yuji Wada, Yasunori Tsukahara, Tomohisa Yamauchi, Tetsuo Sakamoto,         Takumi Kawano

 

Japan Patent Application No. JP2008-060437, Date: 11th  March 2008

 

Title: Synthetic method of indole derivatives.

 

  

(2) Inventors: Makoto Yasuda, Akio Baba, Srinivasarao Arulananda Babu, Yuji Wada, Yasunori Tsukahara, Tomohisa Yamauchi, Tetsuo Sakamoto,         Takumi Kawano

 

Japan Patent Application No. JP2007-260216, Date: 3rd October 2007

 

Title: Synthetic method of β-dicarbonyl compounds.

 

  

(1) Inventors: Akio Baba, Srinivasarao Arulananda Babu, Ikuko Mitani, Masaki Hirano

 

Japan Patent Application No. JP2006-314053, Date: 11th November 2006

Title: Preparation method of aromatic ketones

 

In recent years, the directing group-aided or directing group-free C-H activation/functionalization is considered as a powerful method for installing functional groups in a given organic molecule. While a given organic molecule contains various C-H bonds, one of the main objectives of our research is to accomplish regio- and stereoselective (site-selective) functionalization of C-H bonds of small organic molecules.  Our group is actively working on various projects pertaining to directing group-aided or directing group-free C-H activation/functionalization.
 
 
General Theme
 
 
 
 
 

 
 
 
The metal-mediated additions of nucleophiles to carbonyls or imines are remarkable C-C bond forming synthetic transformations. Our group is involved in using the Barbier-/Reformatksy-type reactions for the stereoselective synthesis of aliphatic chains, carbo- and heterocyclic frameworks related to natural products and bioactive synthetic molecules e.g. isoindolinones, lactones, lactams, amino alcohols, unnatural amino acid derivatives, etc
 
 
 
 
Since the discovery of crown ethers, polyether macrocycles have significantly attracted attention given their invaluable properties and applications in chemical and biological sciences and industry and various methods have been reported for obtaining the macrocycles. Our group is involved in synthesizing novel racemic and optically enriched polyether macrocycles using simple amino acid / amino alcohol building blocks.
 
 
The recovery and reuse of catalysts in organic transformations is an important process in the development of sustainable synthetic protocols in light of green chemistry. Numerous organic transformations have been reported using plethora of heterogeneous catalysts. In recent years, loading the catalysts onto magnetic nanoparticles or using magnetic nanoparticles as the catalysts have received considerable attention because the magnetically supported catalysts can be easily recovered after the desired chemical transformations. Part of our groups research programme is to develop synthetic transformations catalysed by magnetically supported catalysts.
 
 
 
Several classes of small organic molecules including naturally occurring molecules are used for treating Malaria disease. Due to the gradual decrease in the efficacy of some of the drug molecules available for treating Malaria disease, there is a demand for finding new synthetic drug molecules for treating Malaria disease.  Given that there is a demand for finding new synthetic drug molecules for treating Malaria disease one of the objectives of our lab is to synthesize novel oxindoles/trioxanes/tetraoxanes and identify their antimalarial activity.
 
 

Former Group Members

 

Former PhD Students (Graduated with PhD Thesis submission)

 

1. Dr. Nayyar Ahmad Aslam, PhD Thesis, 2016.

 

Thesis Title: Studies on the Stereoselective Barbier-Type Addition Reactions for the Construction of Unnatural Amino Acid Derivatives Having Contiguous Stereocenters

 

2. Dr. Vadla Rajkumar, PhD Thesis, 2016.

 

Thesis Title: Studies on the Stereo and Regioselective Synthesis of New Sets of Functionalized Pyrrolidine, Spiro-Pyrrolidine / Pyrrolizidine, Furfurylamine and 2-/3-(Aminoalkyl)-Thiophene Scaffolds

 

3. Dr. Chennakesava Reddy, PhD Thesis, 2016.

 

Thesis Title: Studies on Stereoselective Construction of Functionalized  Carbo- and Heterocycles Through the Barbier-Type  Reaction and C-H Activation Strategies

 

4. Dr. Naveen, PhD Thesis, 2017.

 

Thesis Title: Studies on The Synthesis of New Classes of Crown Ether-Type/Polyether Macrocycles and Optically Active Aza-Oxo-Thia Polyether Macrocycles

 

5. Dr. Ramarao Parella, PhD Thesis 2017.

 

Thesis Title: Studies on Regio-Stereoselective Synthesis of Functionalized Carbocycles, Heterocycles and Olefins Through the Pd(II)-Catalyzed C-H Activation

 

6. Dr. B. Gopalakrishnan, PhD Thesis 2018.

 

Thesis Title: Studies on Stereoselective Synthesis of Functionalized Aliphatic Chains Containing Stereogenic Centers through the Pd(II)-Catalyzed C-H Activation

 

7. Dr. R. Sankar, PhD Thesis 2018.

 

Thesis Title: Studies on the Ni-Catalyzed Synthesis of Tertiary Amides and Pd-Catalyzed Synthesis of α-Naphthol-Based Triarylmethanes, Ortho-Arylated D-(-)-Phenylglycine Methyl Esters and β-Arylated Keto Acids

 

8. Dr. Narendra Bisht, PhD Thesis 2019 . 

 

Thesis Title: Studies on the Synthesis of Functionalized Arenes and Heteroarenes via Directing Group-Assisted C-H Functionalization

 

9. Dr. R. Padmavathi, PhD Thesis 2020. 

 

Thesis Title: Studies on Pd(II)-catalyzed directing-group aided regioselective C-H functionalization of carboxamides

 

10. Dr. R. Tomar, PhD Thesis 2023.

 

Thesis Title: Studies on the β-C(sp3)-H functionalization toward the synthesis of β-arylated unnatural amino acid derivatives

 

11. Dr. Prabhakar Singh, PhD Thesis 2023.

 

Thesis Title: Studies on Pd(II)-Catalyzed C-H Functionalization of Benzyl Amine, Phenylglycinol, Phenylalaninol, Tyrosine, and ortho-Toluidine Compounds

 

12. Dr. Arup Dalal, PhD Thesis 2024.

 

Thesis Title: Synthesis of polyaryl and functionalized pyrene scaffolds via C-H functionalization

 

13. Dr. Sonam Suwasia, PhD Thesis 2024. (Joint student with Dr. Sugumar's lab)

 

Thesis Title: Synthesis of Modified Azobenzenes and Arylazido Amino Acids Derivatives via C-H Functionalization

 

14. Ms. Ramandeep Kaur, PhD Thesis 2024. 

 

Thesis Title: Studies on the Synthesis of Modified Carbazole Scaffolds via Pd(II)-Catalyzed C-H Functionalization

 

15. Mr. Debabrata Bhattacharya, PhD Thesis 2024.

 

Thesis Title: Synthesis of Sulfonamide-Based Biaryls, Amino Acids and 3-Oxoquinolin-2(1H)-ones via Pd(II)-Catalyzed C-H Functionalization 

 

16. Ms. Shefali Banga (Thesis Submitted).

 

Thesis Title: Assembling of polyaryl-based unnatural amino acid derivatives and modified fluorene and fluorenone scaffolds via C-H functionalization 

 

Former Master's Thesis Students (Graduated with MS Thesis submission)

 

Mr. Jagmohan Solanki, Master’s Thesis, 2013.

Thesis Title: Indium-Promoted Barbier-Type Diastereoselective Allylation of Imino Isatins

 

Mr. Amit Kumar, Master’s Thesis, 2013.

Thesis Title: Magnetically Separable Nano Fe3O4 as Highly Efficient and Reusable Heterogeneous Catalyst for the Regio- and Stereoselective Synthesis of β-Amino Alcohols

 

Ms. Arya J. S., Master’s Thesis, 2015.

Thesis Title: Synthesis of Nitrile Equipped Unnatural Amino Acid Derivatives

 

Ms. Soniya Rani, Master’s Thesis, 2015.

Thesis Title: Zinc- Mediated Nucleophilic Addition of Bromoacetonitrile to Isatin Ketimines

 

Mr. Akshey Sandhu, Master’s Thesis, 2016.

Thesis Title: Synthesis of Biologically Relevant Molecules via Organometallic Methodologies

 

Ms. Sruthi Mohan, Master’s Thesis, 2016.

Thesis Title: Pd(II)-Catalyzed Direct β-Arylation of C(sp3)-H Bonds of Aliphatic and Alicyclic Carboxamides Via One-pot Method

 

Current Members

 

PhD Students:

 

1. Ms. Yashika Aggarwal (PhD student)

 

2. Ms. Pooja Patel (PhD student)

 

3. Ms. Urja Narang (PhD  student)

 

4. Mr. Amit Kumar (PhD student)

 

5. Mr. Subhankar Bodak (PhD student)

 

6. Mr. Amit Kumar (PhD student)

 

7. Mr. Harcharan Singh (PhD student)

 

8. Ms. Kanika Saini (PhD Student, joint student with Dr. S. Saravanamurugan, CIAB)

 

9. Mr. Kshirod Kumar Das (1st year PhD Student)

 

 

 Post-Doc:

 

1. Dr. Prashant Shukla

 

 

 

 

 

 

 

 

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