Research summary
Sinha group’s scientific interests are in the areas of Theoretical Biology, Nonlinear Dynamics and Complex Systems, with a view to understand the logic and design of biological processes. They study the evolution and maintenance of spatiotemporal organization in biological systems spanning multiple scales – from genetic to ecological. Her doctoral thesis was on modelling circadian rhythms, and experimental studies and mathematical modelling of the pattern-forming processes during development of Hydra. Her group used both experimental studies, and mathematical modelling and computational analysis to study – a) intracellular networks in protein structures and biochemical pathways using graph theory and molecular dynamics; b) collective spatiotemporal behaviour and pattern-formation in coupled cell systems (e.g., tissues and organelles); c) single and meta-population dynamics in ecological and epidemiological models – general and disease-specific (Malaria); d) whole genome analysis to study HIV-1 evolution and development of alignment-free methods for classification. Her current research involves analysing epidemiological data of infectious diseases, study host-parasite evolution using genomic data and computational modelling, and using graph theory to understand macroscopic properties of intracellular networks.
Selected Publications
- Uncoupling of ammonia channel as a mechanism of allosteric inhibition in Anthranilate Synthase of Serratia marcescens: dynamic and graph theoretic analysis. Ashutosh Srivastava, Somdatta Sinha. Molecular BioSystems, 13(1), pp142 – 155, 2017 (DOI: 10.1039/c6mb00646a – online Nov 2016).
- Thermostability of In Vitro Evolved Bacillus subtilis Lipase A: A Network and Dynamics Perspective. Ashutosh Srivastava, Somdatta Sinha. PLoS ONE, 9(8): e102856. doi:10.1371/journal.pone.0102856. (2014)
- A Realistic Host-Vector Transmission Model for Describing Malaria Prevalence Pattern. Bulletin of Mathematical Biology. DOI 10.1007/s11538-013-9905-7. Sandip Mandal, Somdatta Sinha and Ram Rup Sarkar, (2013).
- Multi-fractal analysis of HIV-1 genomes. Molecular Phylogenetics and Evolution. Vol. 62, pp 756- 763. Aridaman Pandit, Anil Kumar D., Somdatta Sinha, (2012). Differential Trends in the Codon Usage Patterns in HIV-1 Genes. PLoS ONE. Vol 6 (12): e28889. doi: 10.1371/journal.pone. 0028889. Aridaman Pandit, Somdatta Sinha, (2011).
- Stability of synchronization in a multi-cellular system. Europhysics Letters. Vol 92. 40012. Suma Ghosh, G. Rangarajan, Somdatta Sinha, (2010).
- Propagation of extrinsic perturbation in a negatively auto-regulated pathway. Physical Biology, 4, pp 48-59. R Maithreye, Somdatta Sinha (2007).
- Assortative mixing in Protein Contact Networks and protein folding kinetics. Bioinformatics (Oxford). Vol. 23 no. 14 2007, pages 1760–1767. Ganesh Bagler, Somdatta Sinha, (2007).
- The role of heterogeneity on the spatiotemporal dynamics of host parasite metapopulation. Ecological Modelling. Vol 180, 435-443. B. K. Singh, J. Subba Rao, R. Ramaswamy, Somdatta Sinha, (2004).
- Controlling Dynamics in Spatially Extended Systems. Physical Review E. Vol 65, pp 036227-1to9. Nita Parekh, Somdatta Sinha, (2002).
- Global and Local Control of Spatiotemporal Chaos in Coupled Map Lattices. Physical Reviw Letters. Vol 81, pp 1401-1404. Parekh N., Parthasarathy, S., Somdatta Sinha, (1998).
- Unusual Dynamics of Extinction in a Simple Ecological Model. Proc. Nat. Acad. Sci. (USA). Vol 93, pp 1504 –1508. Somdatta Sinha, Parthasarathy, S., (1996).