Faculty & Staff

Somdatta Sinha
PhD JNU, Delhi
Room No. 4F3
Sector 81
IISER Mohali

Phone: 0172-2293166
Email: ssinha[at]iisermohali.ac.in

Somdatta Sinha

Research summary

Sinha group’s scientific interests are in the areas of Theoretical Biology, Nonlinear Dynamics and Complex Systems, with a view to understand the logic and design of biological processes. They study the evolution and maintenance of spatiotemporal organization  in  biological  systems  spanning  multiple  scales  –  from  genetic  to ecological.   Her   doctoral   thesis   was   on   modelling   circadian   rhythms,   and experimental studies and mathematical modelling of the pattern-forming processes during  development  of  Hydra.  Her  group  used  both  experimental  studies,  and mathematical  modelling  and  computational  analysis  to  study  –  a)  intracellular networks in protein structures and biochemical pathways using graph theory and molecular dynamics; b) collective spatiotemporal behaviour and pattern-formation in coupled cell systems (e.g., tissues and organelles); c) single and meta-population dynamics in ecological and epidemiological models – general and disease-specific (Malaria); d) whole genome analysis to study HIV-1 evolution and development of alignment-free methods for classification. Her current research involves analysing epidemiological data of infectious diseases, study host-parasite evolution using genomic data and computational modelling, and using graph theory to understand macroscopic properties of intracellular networks.



Selected Publications

  • Uncoupling of ammonia channel as a mechanism of allosteric inhibition in Anthranilate Synthase of Serratia marcescens: dynamic and graph theoretic analysis. Ashutosh Srivastava, Somdatta Sinha. Molecular BioSystems, 13(1), pp142 – 155, 2017 (DOI: 10.1039/c6mb00646a – online Nov 2016).
  • Thermostability of In Vitro Evolved Bacillus subtilis Lipase A: A Network and Dynamics Perspective. Ashutosh Srivastava, Somdatta Sinha. PLoS ONE, 9(8): e102856. doi:10.1371/journal.pone.0102856. (2014)
  • A Realistic Host-Vector Transmission Model for Describing Malaria Prevalence Pattern. Bulletin of Mathematical Biology. DOI 10.1007/s11538-013-9905-7. Sandip Mandal, Somdatta Sinha and Ram Rup Sarkar, (2013).
  • Multi-fractal analysis of HIV-1 genomes. Molecular Phylogenetics and Evolution. Vol. 62, pp 756- 763. Aridaman Pandit, Anil Kumar D., Somdatta Sinha, (2012). Differential Trends in the Codon Usage Patterns in HIV-1 Genes. PLoS ONE. Vol 6 (12): e28889. doi: 10.1371/journal.pone. 0028889. Aridaman Pandit, Somdatta Sinha, (2011).
  • Stability of synchronization in a multi-cellular system. Europhysics Letters. Vol 92. 40012. Suma Ghosh, G. Rangarajan, Somdatta Sinha, (2010).
  • Propagation of extrinsic perturbation in a negatively auto-regulated pathway. Physical Biology, 4, pp 48-59. R Maithreye, Somdatta Sinha (2007).
  • Assortative mixing in Protein Contact Networks and protein folding kinetics. Bioinformatics (Oxford). Vol. 23 no. 14 2007, pages 1760–1767. Ganesh Bagler,  Somdatta Sinha, (2007).
  • The  role  of  heterogeneity  on  the  spatiotemporal  dynamics  of  host  parasite  metapopulation. Ecological Modelling. Vol 180, 435-443. B. K. Singh, J. Subba Rao, R. Ramaswamy, Somdatta Sinha, (2004).
  • Controlling Dynamics in Spatially Extended Systems. Physical Review E. Vol 65, pp 036227-1to9. Nita Parekh, Somdatta Sinha, (2002).
  • Global  and  Local  Control  of  Spatiotemporal  Chaos  in  Coupled  Map  Lattices.  Physical  Reviw Letters. Vol 81, pp 1401-1404. Parekh N., Parthasarathy, S., Somdatta Sinha, (1998).
  • Unusual Dynamics of Extinction in a Simple Ecological Model. Proc. Nat. Acad. Sci. (USA). Vol 93, pp 1504 –1508. Somdatta Sinha, Parthasarathy, S., (1996).