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Education

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Teaching

BIO111 - Biology Lab I This laboratory is designed to study cells as the fundamental functional units of life and their diversity. The lab introduces students to major techniques used to study cells and subcellular compartments. Students learn the use of microscopy, cell culture, molecular biology tools, biochemical, and physiological analysis to understand the structure and function of cells.

Publication

Wadjet—Keeping a watchful eye on circular DNA 2025, Corbett* K. D., & Deep*, A.. Structure

Corbett* K. D., & Deep*, A. 2025, Wadjet—Keeping a watchful eye on circular DNA. Structure

Bellaart#, A., Brambilla#, A., Xu#, J., Mendez-Diaz, F., Deep, A., Anzola, J., Meitinger, F., Ohta, M., Corbett K. D., Desai* A., Oegema* K. 2025, TRIM37 employs peptide motif recognition and detection of substrate oligomerization to prevent ectopic spindle pole assembly. Nature Structural Molecular Biology

Armbruster, E. G.#, Rani, P.#, Lee, J., Klusch, N., Hutchings, J., Hoffman, L. Y., Buschkaemper, H., Enustun, E., Adler, B. A., Inlow, K., VanderWal, A. R., Hoffman, M. Y., Daksh, Aindow, A., Deep, A., Rodriguez, Z. K., Morgan, C. J., Ghassemian, M., Laughlin, T. G., Charles, E., Cress, B. F., Savage, D. F., Doudna, J. A., Pogliano, K., Corbett, K. D., Villa*, E., Pogliano*, J 2025, Sequential membrane- and protein-bound organelles compartmentalize genomes during phage infection. Cell Host & Microbe

Gu, Y., Li, H., Deep, A., Enustun, E., Zhang*, D. & Corbett*, K. D. 2025, Bacterial Shedu immune nucleases share a common enzymatic core regulated by diverse sensor domains. Molecular Cell

Pradhan#, B., Deep#, A., Konig, J., Baaske, M. D., Corbett*, K. D. & Kim*, E. 2025, Loop-extrusion-mediated plasmid DNA cleavage by the bacterial SMC Wadjet complex. Molecular Cell

Deep*, A., Liang, Q., Enustun, E., Pogliano, J. & Corbett*, K. D. 2024, Architecture and infection-sensing mechanism of the bacterial PARIS defense system. Nature

Houston, J., Vissotsky, C., Deep, A., Hakozaki, H., Crews, E., Oegema, K., Corbett, K. D., Lara-Gonzalez, P., Kim*, T. & Desai*, A. 2024, Phospho-KNL-1 recognition by a TPR domain targets the BUB-1/BUB-3 complex to C. elegans kinetochores. Journal of Cell Biology

Enustun, E., Armbruster, E. G., Lee, J., Zhang, S., Yee, B. A., Malukhina, K., Gu, Y., Deep, A., Naritomi, J. T., Liang, Q., Aigner, S., Adler, B. A., Cress, B. F., Doudna, J. A., Chaikeeratisak, V., Cleveland, D. W., Ghassemian, M., Bintu, B., Yeo, G. W., Pogliano*, J. & Corbett*, K. D. 2024, A phage nucleus-associated RNA-binding protein is required for jumbo phage infection. Nucleic Acids Research

Abasi, L. S., Elathram, N., Movva, M., Deep, A., Corbett, K. D. & Debelouchina, G. T. 2024, Phosphorylation regulates tau’s phase separation behavior and interactions with chromatin. Communications Biology

Enustun, E., Deep, A., Gu, Y., Nguyen, K. T., Chaikeeratisak, V., Armbruster, E., Ghassemian, M., Villa, E., Pogliano*, J. & Corbett*, K. D. 2023, Identification of the bacteriophage nucleus protein interaction network. Nature Structural and Molecular Biology

Houston, J., Ohta, M., Gomez-Cavazos, J. S., Deep, A., Corbett, K. D., Oegema, K., Lara-Gonzalez, P., Kim*, T. & Desai*, A. 2023, BUB-1-bound PLK-1 directs CDC-20 kinetochore recruitment to ensure timely embryonic mitoses. Current Biology

Deep#, A., Singh#, L., Kaur#, J., Velusamy, M., Bhardwaj, P., Singh, R. & Thakur, K. G. 2023, Structural insights into Mycobacterium tuberculosis DarT toxin neutralization by cognate DarG antitoxin: ssDNA mimicry by DarG C-terminal domain keeps the DarT toxin inhibited. Structure

Deep#, A., Gu#, Y., Gao, Y. Q., Ego, K. M., Herzik, M. A., Zhou, H. & Corbett, K. D. 2022, The SMC-family Wadjet complex protects bacteria from plasmid transformation by recognition and cleavage of closed-circular DNA. Molecular Cell

Laughlin#, T. G., Deep#, A., Prichard, A. M., Seitz, C., Gu, Y., Enustun, E., Suslov, S., Khanna, K., Birkholz, E. A., Armbruster, E., McCammon, J. A., Amaro, R. E., Pogliano*, J., Corbett*, K. D. & Villa*, E. 2022, Architecture and self-assembly of the jumbo bacteriophage nuclear shell. Nature

Rathore, Y., Shukla, J., Laroiya, I., Deep, A., Lakhanpal, T., Kumar, R., Singh, H., Bal, A., Singh, G., Gopal Thakur, K. & Mittal, B. R. 2022, Development 68Ga trastuzumab Fab and bioevaluation by PET imaging in HER2/neu expressing breast cancer patients. Nuclear Medicine Communications

Agarwal, S., Sharma, A., Bouzeyen, R., Deep, A., Sharma, H., Mangalaparthi, K. K., Datta, K. K., Kidwai, S., Gowda, H., Varadarajan, R., Sharma, R. D., Thakur, K. G. & Singh, R. 2020, VapBC22 toxin-antitoxin system from Mycobacterium tuberculosis is required for pathogenesis and modulation of host immune response. Science Advances

Kaundal, S., Deep, A., Kaur, G. & Thakur, K. G. 2020, Molecular and biochemical characterization of YeeF/YezG, a polymorphic toxin-immunity protein pair from Bacillus subtilis. Frontiers in Microbiology

Deep, A., Tiwari, P., Agarwal, S., Kaundal, S., Kidwai, S., Singh*, R. & Thakur*, K. G. 2018, Structural, functional, and biological insights into the role of Mycobacterium tuberculosis VapBC11 toxin-antitoxin system: targeting a tRNase to tackle the mycobacterial adaptation. Nucleic Acids Research

Agarwal, S., Tiwari, P., Deep, A., Kidwai, S., Gupta, S., Thakur, K. G. & Singh, R. 2018, System-wide analysis unravels the differential regulation and in vivo essentiality of virulence-associated proteins B and C Toxin-Antitoxin systems of Mycobacterium tuberculosis. The Journal of Infectious Diseases

Deep, A., Kaundal, S., Agarwal, S., Singh, R. & Thakur, K. G. 2017, Crystal structure of Mycobacterium tuberculosis VapC20 toxin and its interactions with cognate antitoxin, VapB20, suggest a model for toxin-antitoxin assembly. FEBS Journal

Mawatwal, S., Behura, A., Ghosh, A., Kidwai, S., Mishra, A., Deep, A., Agarwal, S., Saha, S., Singh, R. & Dhiman, R. 2017, Calcimycin mediates mycobacterial killing by inducing intracellular calcium-regulated autophagy in a P2RX7 dependent manner. Biochimica et Biophysica Acta (BBA) – General Subjects

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Department of Biological Sciences

Amar Deep

Assistant Professor

Research