Research publications
1.Shukla, C. P., A. K. Bachhawat and N. Sathyamurthy (1982). The challenge of fitting ab initio surfaces. The rigid rotor CO2-H2 potential. Chemical Physics, 70, 83-91.
2. Bachhawat, A. K. and S. Ghosh (1987). Isolation and characterization of outer membrane proteins of Azospirillum brasilense. J.Gen.Microbiology, 133, 1751-1758.
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3.Bachhawat, A. K. and S. Ghosh (1987). Iron transport in Azospirillum brasilense: Role of the siderophore, spirilobactin. J.Gen. Microbiology, 133, 1759-1765.
4.Bachhawat, A. K. and S. Ghosh (1989). Temperature sensitive siderophore production in Azospirillum brasilense.J.Bacteriology, 171, 4092-4094.
5. Shashi, K., A. K. Bachhawat and R. Joseph (1990). ATP:citrate lyase of Rhodotorula gracilis. Purification and Properties.
Biochim. Biophys. Acta, 1033, 23-30.
6. Bachhawat, A. K. and S.Pillai (1991). Distinct intracellular fates of membrane and secretory immunoglobulin heavy chains in a pre-B cell line. J.Cell Biology, 115, 619-624.
7. Bachhawat, A. K., M. F. Manolson, D. Murdock , D. Garman and E.W.Jones. (1993). The VPH2 gene encodes a 25 kDa protein required for in vivo activity of the yeast vacuolar H+-ATPase. Yeast, 175-184.
8. Bachhawat,A. K., J.Suhan and E.W.Jones (1994). The yeast homolog of H<>58, a mouse gene essential for embryogenisis, is required for delivery proteins to the vacuole. Genes and Development, 8, 1379-1387.
9. Kaur, R., R.Kumar and A.K.Bachhawat (1995). Selective recovery of DNA fragments from silica particles: Effect of A-T content and elution conditions. Nucleic Acids Research, 23, 4932-4933.
10. Chaudhuri, B., S. Ingavale and A.K.Bachhawat. (1997). apd1+, a gene required for red pigment formation in ade6 mutants of Schizosaccharomyces pombe, encodes an enzyme required for glutathione biosynthesis: A role for glutathione and a glutathione-conjugate pump. Genetics ,145, 75-83.
11. Kaur, R. Ingavale, S.S. and A.K.Bachhawat (1997). PCR-mediated direct gene disruption in Schizosaccharomyces pombe. Nucl. Acids Research, 25, 1080-1081.
12. Ingavale S.S., Kaur, R., Aggarwal, P. and A.K.Bachhawat (1998). A minisaatellite sequence within the propeptide region of the vacuolar carboxypeptidase Y gene of Schizosaccharomyces pombe. J. Bacteriology, 180, 3727-3729.
13. Kaur, R. and A.K. Bachhawat (1999). The yeast multidrug resistance protein, pdr5p, confers reduced drug resistance in the erg mutants of Saccharomyces cerevisiae. Microbiology, 145, 809-819.
14. Ingavale, S.S. and A.K. Bachhawat (1999). Restoration of inositol protrophy by the Pichia pastoris INO1 gene in Schizosaccharomyces pombe. Microbiology, 145, 1903-1910.
15. Ho, S.C., Chaudhuri, S., Bachhawat, A.K. , K.McDonald and S.Pillai (2000). Accelerated proteasomal degradation of membrane immunoglobulin heavy chains.
J.Immunology 164, 4713-4719.
16. Bourbouloux, A#., Shahi, P.#, Chakladhar, A., Delrot, S. and A. K. Bachhawat (2000). Hgt1p, a high affinity glutathione transporter from the yeast Saccharomyces cerevisiae. J. Biol. Chem. 275, 13259-13267.
# Equal contributions by these authors
17. Ingavale, S.S. Sharma, K.G. and A.K. Bachhawat (2000). Construction of novel vectors for use in the fission yeast Schizosaccharomyces pombe, Yeast,16, 1345-1350.
18. Sharma, K.G., Sharma, V., Bourbouloux, A., Delrot, S. and A.K. Bachhawat (2000). Delayed growth stasis upon glutathione depletion in Saccharomyces cerevisiae : Evidence for an overlapping role played by thioredoxin. Current Genetics, 38, 71-77.
19. Subba Rao,G., Bachhawat, A.K. and C.M.Gupta (2002) Two-hybrid based analyses of protein-protein interactions of the yeast multidrug resistance protein, Pdr5p. Functional & Integrative Genomics, 1 (6), 357-366, 2002.
20. Sharma, K.G#., Mason,D.L#, Liu,G., Rea, P.A., Bachhawat, A.K., and Michaelis,S. (2002) Localization, regulation and substrate transport properties of Bpt1p, a Saccharomyces cerevisiae MRP-type ABC transporter.
Eukaryotic Cell, 1, 391-400, 2002.
# Equal contributions by these authors
21. Kumar, C. , Rakesh Sharma and A.K. Bachhawat
Utilization of glutathione as an exogenous sulphur source is independent of -glutamyl transpeptidase in the yeast Saccharomyces cerevisiae: Evidence for an alternative gluathione degradation pathway
FEMS Microbiology Letters, 219:187-94,2003
22. Kohli, DK and A.K. Bachhawat
CLOURE: Clustal Output Reformatter, a program for reformatting Clustal X/ Clustal W outputs for SNP analysis and molecular systematics
Nucleic Acids Research, 31: 3501, 2003
23. Kumar,C., Rakesh Sharma and A.K. Bachhawat
Investigations into the polymorphisms at the ECM38 locus of two widely used S.cerevisiae S288C strains, YPH499 and BY4742. Yeast. 20 :857-63. 2003
24. Sharma, K.G. Kaur, R., A.K. Bachhawat
The glutathione-mediated detoxification pathway in yeast: an analysis using the red pigment that accumulates in certain adenine biosynthetic mutants of yeasts reveals the involvement of novel genes.
Archives of Microbiology 180:108-17, 2003
25. Ganguly, D. , C.V.Srikanth, Chitranshu Kumar, Purva Vats and A. K Bachhawat
Why is glutathione ( a tripeptide) synthesized by specific enzymes while TSH releasing hormone (TRH or thyroliberin), also a tripeptide, is produced as part of a prohormone protein ?
[Is there an answer ?] IUBMB Life 55, 553-554, 2003.
26. Zhang,M-Y., Andrée Bourbouloux, Olivier Cagnac, C.V. Srikanth , Doris Rentsch, A.K. Bachhawat and Serge Delrot
A novel family of transporters mediating the transport of glutathione derivatives in plants.
Plant Physiology 134(1):482-91, 2004.
27. Sutar, R., Joseph K. David, K. Ganesan, Anup K. Ghosh, Sunit Singhi, Arunaloke Chakrabarti, and A.K. Bachhawat . Comparison of ITS and IGS1 region for strain typing of clinical and non-clinical isolates of Pichia anomala J.Med Microbiol 53:119-23, 2004.
28. Kohli, D , C.V. Srikanth and A. K. Bachhawat . A Search Tool for Identification and Analysis of Conserved Sequence Patterns in Saccharomyces spp. orthologous promoters.
In Silico Biology 4, 411-415 (2004).
29.C.V. Srikanth, A.K.Chakraborti and A. K. Bachhawat.Acetaminophen toxicity and resistance in the yeast Saccharomyces cerevisiae. Microbiology, 151:99-111. 2005.
30.C. V. Srikanth, P. Vats, A. Bourbouloux, S. Delrot and A. K Bachhawat Multiple cis-regulatory elements and the yeast sulphur regulatory network are required for the regulation of the yeast glutathione transporter, Hgt1p. Current Genetics, 47, 345-358, 2005.
31. Bachhawat, A.K. Comparative Genomics: A powerful New tool in Biology, Resonance, 22-40, 2006.
32. Ganguli D, Kumar C, Bachhawat A.K.. ( 2007). The alternative pathway of glutathione degradation is mediated by a novel protein complex involving three new genes in Saccharomyces cerevisiae. Genetics. 175,1137-1151,2007.
33. Bhardwaj, S., Sutar,R., Bachhawat,A.K., Singhi,S. Chakrabarti,A. ( 2007). PCR-based identification and strain typing of Pichia anomala using the ribosomal intergenic spacer region IGS1. J.Med. Microb. 56,185-189, 2007.
34. Kaur, J. and Bachhawat, A.K.( 2007) Yct1p, a novel, high-affinity, cysteine specific transporter from the yeast Saccharomyces cerevisiae. Genetics 176, 877-890, 2007.
35. Thakur, A., Kaur, J. and Bachhawat, A.K (2008). Pgt1, a glutathione transporter from the fission yeast, Schizosaccharomyces pombe. FEMS Yeast Research 8, 916-929.
36. Kaur, J. and Bachhawat, A.K. (2009) A modified western blot protocol for enhanced detection of a membrane protein. Analytical Biochemistry. 384:348-9, 2009.
37. Kaur H, Kumar C, Junot C, Toledano M, Bachhawat AK (2009) Dug1p is a Cys-Gly peptidase of the gamma -glutamyl cycle of Saccharomyces cerevisiae, and represents a novel family of Cys-Gly peptidases. J Biol Chem. 284:14493-502.
38.Kaur, J., Srikanth C.V., and Bachhawat, A.K (2009). Differential roles played by the native cysteine residues of the yeast glutathione transporter, Hgt1p. FEMS Yeast Research. 9, 849-866, 2009.
39.Kaur, J. and Bachhawat, A.K. (2009). Q222 in transmembrane domain 4 and Q526 in transmembrane domain 9 are critical for substrate recognition in the yeast high affinity glutathione transporter, Hgt1p.
J Biol Chem 284(35):23872-84
40. Kumar, A. and Bachhawat, A.K. (2010). Is a futile cycle, formed between two ATP-dependant -glutamyl cycle enzymes, -glutamyl cysteine synthetase and 5-oxoprolinase, the cause of cellular ATP depletion seen in nephrotic cystinosis? J.Biosciences 35 :21-5, 2010.
41. Kumar, A. and Bachhawat,A.K.* (2010) OXP1/YKL215c encodes an ATP-dependant 5-oxoprolinase in Saccharomyces cerevisiae: Functional Characterization, Domain structure and Identification of actin–like ATP-binding motifs in eukaryotic 5-oxoprolinases.
FEMSYeastRes.10:394-401.
42. Thakur,A and Bachhawat, A.K. (2010) The role of transmembrane helix 9 in substrate recognition by the fungal high affinity glutathione transporters. Biochem. J. 429:593–602.
43. Yadav, AK, Desai, PR, Rai, MN, Kaur R, Ganesan, K and Bachhawat, AK (2011) Glutathione biosynthesis in the yeast pathogens Candida glabrata and Candida albicans: Essential in C. glabrata, and essential for virulence in C. albicans . Microbiology 157, 484-495.
44.Kumar, C, Igbaria, A, D’Autreaux, B., Planson, A-G., Junot, C., Bachhawat, AK, Deluanay-Moisan, A and Toledano, M. (2011). Glutathione revisited : a vital function in iron metabolism but a secondary role in thiolredox maintenance. EMBO J. 30: 2044-56, 2011.
45. Yadav, AK and Bachhawat,AK (2011) CgCYN1, a plasma membrane cystine-specific transporter ofCandida glabrata with orthologues prevalent amongst pathogenic yeasts and fungi.
J Biol Chem. 286:19714-23,2011.
46. Desai PR, Thakur A, Ganguli D, Paul S, Morschhauser J, BachhawatAK (2011). Glutathione utilization by Candida albicans requires a functional DUG pathway and OPT7, an unusual member of the oligopeptide transporter family. J Biol Chem. 286:41183-94.
47.Kumar, A , Bachhawat, A.K.(2012) Pyroglutamic acid: throwing light on a lightly studied metabolite.
Current Science,102:288-297.
48. Kaur H, Ganguli D, BachhawatAK.(2012).Glutathione degradation by the alternative pathway (DUG pahway) in Saccharomyces cerevisiae is initiated by the (Dug2p-Dug3p)2 complex, a novel GATase enzyme acting on glutathione.J Biol Chem. 287:8920-31.
49. Kumar A, Tikoo S, Maity S, Sengupta S, Sengupta S, Kaur A, Bachhawat AK. (2012) Mammalian proapoptotic factor ChaC1 and its homologues function as γ-glutamyl cyclotransferases acting specifically on glutathione.EMBO Reports. 13:1095-101.
50. Bachhawat AK, Thakur A, Kaur J, Zulkifli M.(2012). Glutathione transporters. Biochim Biophys Acta. 2012 Nov 30. doi:pii: S0304-4165(12)00338-8. 10.1016/j.bbagen.2012.11.018. [Epub ahead of print].
51. Thakur A, Bachhawat AK. (2013). Mutations in the N-terminal region of the Schizosaccharomyces pombe glutathione transporter pgt1⁺ allows functional expression in Saccharomyces cerevisiae.
Yeast. 30:45-54.
52. Kumar S, Kasturia N, Sharma A, Datt M, Bachhawat AK.(2013). Redox-dependent stability of the γ-glutamylcysteine synthetase enzyme of Escherichia coli: a novel means of redox regulation.
Biochem J. 449:783-94
